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We do not yet understand the immune system glitches that push B lymphocytes to inappropriately respond to islet autoantigens, engage autoreactive T cells, and morph into autoantibody-secreting cells. Dr. Bonami’s work has also focused on identifying and correcting defects in immune tolerance mechanisms in the setting of autoimmune disease. Vanderbilt Pathology Laboratory Services; Global Health; Calendars ; Calendars. Telomeres: The ends of chromosomes (telomeres) constitute a tiny fraction of DNA in a cell, but play a central role in genome stability and cellular lifespan. ... Aune Lab Boothby Lab Bonami Lab Jin Chen Lab Chung Lab Crofford Lab Major Lab Ormseth Lab C. Michael Stein Lab Thomas Laboratory Lab. Neilson Society. ​Type 1 diabetes occurs as the result of autoimmune destruction of beta cells in the pancreas. In 2015 the Vanderbilt Diabetes Research and Training Center presented her with the Daryl K. Granner Scholar in Diabetes Postdoctoral Fellow Award, Ph.D.. Dr. Bonami has received a grant from the Juvenile Diabetes Research Foundation (JDRF). Thomas BRET (Biomedical Research Education and Training) Faculty Page Hypertension is a leading cause of worldwide morbidity and mortality, leading to stroke, myocardial infarction, vascular disease, and chronic kidney disease. C. Michael Stein Lab. rachel.h.bonami@vanderbilt.edu. Rachel H. Bonami, PhD. Dr. Bonami has shown that anti-insulin B lymphocytes can be selectively eliminated using a monoclonal antibody to prevent type 1 diabetes in a preclinical model. CURRENT LAB MEMBERS James W. Thomas, II, M.D. Faculty Member, Vanderbilt Diabetes Research and Training Center. Office Address. Featured community. Advanced Therapeutics. Preserving gut mucus architecture. Division of Rheumatology and Immunology, Department of Medicine. Ph.D., Microbiology and Immunology, Vanderbilt University, Nashville, Tennessee B.S., Microbiology and Cell Sciences, University of Florida, Gainesville, Florida. Vanderbilt University Medical Center is committed to principles of equal opportunity and affirmative action. Thomas Lab Current Lab Members . My laboratory investigates lung inflamamtion/injury, remodeling, fibrosis, and development of lung cancer. This is a 3-year Strategic Research Agreement. About. ‪Vanderbilt University‬ - ‪Cited by 79‬ - ‪Drug Delivery‬ - ‪Biomaterials‬ Citations per year. In 2015 the Vanderbilt Diabetes Research and Training Center presented her with the Daryl K. Granner Scholar in Diabetes Postdoctoral Fellow Award, Ph.D.. Research Description Dr. Bonami has received a grant from the Juvenile Diabetes Research Foundation (JDRF). This is a 3-year Strategic Research Agreement. Thomas Publications. It’s also why we’ve ramped down laboratory research operations. The Kendall Lab investigates the immunologic pathophysiology of Type 1 diabetes (T1D), with a focus on the role of B lymphocytes. Rachel Henry Bonami, Ph.D., Postdoctoral Fellow, Division of Rheumatology and Immunology, Department of Medicine, rachel.h.bonami@vanderbilt.edu. If you're super-interested in our research, feel free to e-mail rachel.h.bonami@vumc.org and I'll keep you in mind if positions open in the future! She was previously awarded a postdoctoral fellowship by the Juvenile Diabetes Research Foundation and was invited to present her work at Keystone Symposia and at the American Association of Immunologists annual meeting. Wan X, Thomas JW, Unanue ER.Class-switched anti-insulin antibodies originate from unconventional antigen presentation in multiple lymphoid sites.J. She was previously awarded a postdoctoral fellowship by the Juvenile Diabetes Research Foundation and was invited to present her work at Keystone Symposia and at the American Association of Immunologists annual meeting. 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